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Test Name:
Interferon Beta Neutralizing Antibody with Reflex to Titer


  • TMF No:
    45783
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    IFNB NEU R
  • CPT Code:
    86352
  • Ref Lab Test No:
    2003390
  • Test Includes:

    Interferon Beta Screen

    Reflexive Testing:
    If Interferon Beta Neutralizing Antibody screen result is positive, then Interferon Beta Neutralizing Antibody titer will be performed. Additional charges apply.
    45784 zz.BILLONLY: Interferon Beta Neutralizing Antibody Titer

  • Also Known As:
    Anti-IFN-b; Anti-IFNb; IFN-beta Antibody; NAbFeron
  • Patient Prep:
    Collect specimens before Interferon beta treatment, or more than 48 hours following the most recent dose. Patient should not be on steroid therapy in excess of 10 mg prednisolone (or equivalent) daily. High endogenous levels of Interferon beta, alpha, or gamma may interfere with this assay.
  • Spec Collect:
    Gold top (SST) or Red top (serum) tube. Mix by inverting tube 5 times.
  • Spec Process:
    Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to a screw-capped plastic transport tube. (Min: 0.3 mL)
  • Spec Store Transport:
    Refrigerated.
  • Spec Stability:
    After separation from cells:
    Room temperature: 48 hours
    Refrigerated: 2 weeks
    Frozen: 4 months (avoid repeated freeze/thaw cycles)
  • Spec Reject:
    Contaminated, hemolyzed, icteric, or lipemic specimens.
  • Methodology:
    Cell Culture; Chemiluminescent Immunoassay (CLIA)
  • Use:
    Aids in management of individuals treated with interferon beta.
  • Interpretive Data:

    Interferon Beta Screen
    Negative

    Interferon Beta Titer
    Less than 20: Negative
    20 to 99: Moderate levels of neutralizing antibodies present
    100 or greater: High levels of neutralizing antibodies present

    Interpretive Data:
    A titer of 20 to 99 suggests moderate levels of neutralizing antibodies present. A titer of 100 or greater suggests high levels of neutralizing antibodies present. Either case warrants continued patient monitoring. The titer is reported as the reciprocal of the dilution of patient serum that reduces the interferon activity by 10 fold.

    See Compliance Statement B: www.aruplab.com/CS
    Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    Note:
    If Interferon Beta Neutralizing Antibody screen result is positive, then Interferon Beta Neutralizing Antibody titer will be added.

    This test is performed pursuant to an agreement with Biomonitor.

  • Day Run:
    Thu
  • Time Reported:
    2-16 days
  • Test Type:
    IMMUNOLOGY