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Test Name:
Immune Complex Panel

  • TMF No:
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
  • CPT Code:
  • Ref Lab Test No:
  • Test Includes:
    C1Q Binding Assay; Raji Cell Immune Complex Assay
  • Also Known As:
    Circulating Immune Complex Panel; Circulating Immune Complexes
  • Also See:
    44042 C1Q Binding Assay
    44531 Raji Cell Immune Complex Assay
  • Spec Collect:
    Red top (serum) or Gold top (SST) tube. Mix by inverting tube 5 times.
  • Spec Process:
    Allow complete clotting of red blood cells (up to 1 hour), then separate serum from cells within 30 minutes. Transfer two 1 mL serum aliquots to screw-capped plastic transport tubes and freeze immediately. (Min: 0.5 mL per aliquot)
  • Spec Store Transport:
    CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
  • Spec Stability:

    Room temperature or Refrigerated: Unacceptable
    Frozen: 30 days

    C1q: (After separation from cells):
    Room temperature: 2 hours
    Refrigerated: Unacceptable
    Frozen: 2 weeks (avoid repeated freeze/thaw cycles)

  • Spec Reject:
    Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles.
  • Methodology:
    Quantitative Flow Cytometry; Semi-Quantitative Enzyme-Linked Immunosorbent Assay
  • Interpretive Data:

    Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.

    Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders.

    ASR Compliance Statement:
    Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

    Immune complexes bind to Raji Cells via their complement receptors. The immunoglobulin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.

  • Day Run:
  • Time Reported:
    3-10 days
  • Test Type: