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Test Name:
Insulin Antibody


  • TMF No:
    44387
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    INSUL AB
  • CPT Code:
    86337
  • Ref Lab Test No:
    0099228
  • Also Known As:
    Anti-Insulin; Human Insulin Antibodies; Insulin Ab; Insulin Antibodies; Insulin Autoantibodies
  • Ordering Guidance:
    • Use to determine presence of antibodies to endogenous insulin or exogenous insulin analogues. Testing not recommended for patients receiving insulin >2 weeks, as insulin antibody formation may occur.
    • If pursuing antibody testing to determine autoimmune diabetes mellitus, perform at least 2 antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Glutamic Acid Decarboxylase Antibody, IA-2 Antibody, Islet Cell Cytoplasmic Antibody, IgG, and Zinc Transporter 8 Antibody.
    • Do not use to differentiate type 1 DM from type 2 DM, for most cases.
  • Also See:
    28276 Glutamic Acid Decarboxylase Antibody
    45486 IA-2 Antibody
    44250 Islet Cell Cytoplasmic Antibody, IgG
    47380 Zinc Transporter 8 Antibody
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or Red top (serum) tube
  • Pref Vol:
    0.5 mL
  • Min Vol:
    0.1 mL
  • Spec Collect:
    Normal phlebotomy procedure. Mix by inverting tube 5 times.
  • Spec Process:
    Transfer serum to a screw-capped plastic transport tube.
  • Spec Store Transport:
    Frozen.
  • Spec Stability:
    After separation from cells:
    Room temperature: 24 hours
    Refrigerated: 1 week
    Frozen: 2 months
  • Spec Reject:
    Plasma. Hemolyzed or lipemic specimens.
  • Methodology:
    Semi-Quantitative Radioimmunoassay (RIA)
  • Interpretive Data:

    A value greater than 0.4 Kronus Units/mL is considered positive for Insulin Antibody. Kronus units are arbitrary.
    Kronus Units=U/mL.

    This assay is intended for the semi-quantitative determination of antibodies to endogenous insulin or antibodies to exogenous insulin in human serum. Antibodies to exogenous insulin therapies may be detected using this method. The magnitude of the measured result is not related to disease progression. Results should be interpreted within the context of clinical symptoms.

  • Additional Test Info:
    Additional Technical Information
    Lab Tests Online
  • Day Run:
    Tue, Wed, Fri
  • Time Reported:
    3-6 days
  • Test Type:
    IMMUNOLOGY