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Test Name:
Isavuconazole, Serum


  • TMF No:
    43679
  • Performance Lab Name:
    Viracor Eurofins Clinical Diagnostics
  • Test Mnemonic:
    CRESEMBA
  • CPT Code:
    80299
  • Ref Lab Test No:
    4900 | 4910
  • Also Known As:
    CRESEMBA®
  • Spec Collect:
    Red top (serum) tube. Mix by inverting tube 5 times.
  • Spec Process:
    Allow specimen to clot for 30 to 60 minutes at room temperature. Centrifuge to separate from cells and transfer 1 mL serum to a screw-capped plastic transport tube. (Min: 0.5 mL)
  • Spec Store Transport:
    Frozen on dry ice.
  • Spec Reject:
    Non-frozen specimens. Whole blood. Gel separator tubes.
  • Methodology:
    Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  • Use:
    Therapeutic Drug Monitoring
  • Clinical Significance:
    Isavuconazole is for the treatment of life threatening fungal infections, specifically invasive aspergillosis and invasive mucormycosis. There is a significant need for alternative antifungal therapies that address some of the limitations of voriconazole, such as reduced potential for nephrotoxicity for the intravenous formulation, in addition to other dose-related toxicities. Given the difficulty in diagnosis and similarity with which infections may present, having an antifungal that is effective for both indications would be particularly useful to physicians treating immunocompromised patients.
  • Interpretive Data:

    Assay Range: 0.1 to 10 mcg/mL.

    This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.

  • Day Run:
    Mon-Sat
  • Time Reported:
    Same day as specimen receipt at Viracor-IBT Laboratories
  • Test Type:
    TOX-TDM