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Test Name:
IGF Binding Protein-1


  • TMF No:
    43625
  • Performance Lab Name:
    Quest Diagnostics Nichols Institute, SJC
  • Test Mnemonic:
    IGFBP1
  • CPT Code:
    83519
  • Ref Lab Test No:
    36590
  • Also Known As:
    IGFBP-1; Insulin-Like Growth Factor Binding Protein-1
  • Ordering Guidance:
    For suspected growth hormone disorders, insulin-like growth factor 1 (IGF-1) and growth hormone testing is recommended.
  • Also See:
    30029 Growth Hormone
    30053 Insulin-Like Growth Factor 1
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or Red top (serum) tube
  • Pref Vol:
    1 mL
  • Min Vol:
    0.2 mL
  • Patient Prep:
    Overnight fasting is required.
  • Spec Collect:
    Normal phlebotomy procedure. Mix by inverting tube 5 times.
  • Spec Process:
    Allow specimen to clot completely at room temperature. Centrifuge to separate from cells and transfer serum to a screw-capped plastic transport tube.
  • Spec Store Transport:
    Refrigerated.
  • Spec Stability:
    After separation from cells:
    Room temperature: 24 hours
    Refrigerated: 1 week
    Frozen: 4 weeks
  • Spec Reject:
    Grossly hemolyzed or lipemic specimens.
  • Methodology:
    Radioimmunoassay (RIA)
  • Clinical Significance:
    The concentration of IGFBP-1 is correlated with glycemic conditions. IGFBP-1 may be used for monitoring insulin responsiveness, as a marker for insulin-producing tumors, monitoring acute fluctuations in insulin action, and determining if poor glycemic control is due to inadequate insulin treatment or poor control of dietary intake.
  • Interpretive Data:
    This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
  • Day Run:
    Tue
  • Time Reported:
    4-16 days
  • Test Type:
    HORMONE